7th ISAN: Congress of the International Society for Autonomic Neuroscience

MONDAY - SEPTEMBER 12

MONDAY, SEPTEMBER 12, 2011
10:00-20:00	Registration
ISAN/AAS WORKSHOP Clinical Assessment of the Autonomic Nervous System Which Tests For What Problems?
13:00-13:05	Welcome and Introduction Mark W. Chapleau, USA
13:05-13:20	Autonomic Systems: Pathways, Effectors & Pathophysiologic Correlates David S. Goldstein, USA
Assessment of the Autonomic Nervous System in Autonomic Disorders Chairs: Antonio C. Nobrega, Brazil and Nicola Montano, Italy
13:20-13:40	Orthostatic Hypotension, Intolerance & Syncope Benjamin Levine, USA
13:40-13:50	Discussion
13:50-14:10
14:10-14:20	Discussion
14:20-14:40	Autonomic Neuropathies Roy Freeman, USA
14:40-14:50	Discussion
14:50-15:10	Synucleinopathies – Neurodegenerative Diseases David S. Goldstein, USA
15:10-15:20	Discussion
15:20-15:35	COFFEE BREAK
15:35-15:50	Gastrointestinal Disorders Gisela Chelimsky, USA
15:50-15:55	Discussion
15:55-16:10	Bladder/Urinary Disorders Thomas Chelimsky, USA
16:10-16:15	Discussion
16:15-16:35	Novel Strategies in Autonomic Basic and Clinical Research David Robertson, USA
16:35-16:45	Discussion
16:45-17:00	Open Discussion and Adjourn Chair: Felicia Axelrod
18:30-19:00	WELCOME TO ISAN/AAS 2011 Sérgio Cravo, Chair of the Local Organizing Committee Mark W. Chapleau and Julian F.R. Paton, Co-Chairs of the Program Committee Jean-Pierre Timmermans, President of ISAN Michael J. Joyner, President of AAS
19:00-20:00	OPENING PLENARY LECTURE Introduced by Jean-Pierre Timmermans, Belgium Purinergic Signalling: Pathophysiology and Therapeutic Potential Geoffrey Burnstock, University College Medical School, London, UK
20:00	WELCOME COCKTAIL

TUESDAY - SEPTEMBER 13

TUESDAY, SEPTEMBER 13, 2011
8:00-10:00	Symposia 1 and 2
Symposium 1 Afferent Baroreflex Dysfunction: From Molecules to Man Chairs: Horacio Kaufmann, USA and Mark W. Chapleau, USA
8:00-8:25	Introduction: afferent vs. efferent baroreflex dysfunction and failure Horacio Kaufmann, USA
8:25-8:50	Heritable and environmental factors influencing baroreflex control of blood pressure in humans Jens Jordan, Germany
8:50-9:15	Molecular determinants of afferent baroreflex function, insights from mouse models Mark W. Chapleau, USA
9:15-9:40	Familial dysautonomia: a genetic disease with afferent baroreflex failure Lucy Norcliffe-Kaufmann, USA
9:40-9:55	Preserved cardiovascular reflex regulation in patients with continuous flow left ventricular assist device Jens Tank, D Malehsa, K Heusser, K Hegemann, A Diedrich, C Bara, J Jordan, M Strueber. Hannover, Germany and Nashville, TN, USA
9:55-10:00	General Discussion
10:00-10:15	COFFEE BREAK
Symposium 2 Bladder to Brain; Autonomic Basis of Urinary Dysfunction Chairs: Marcus Drake, UK and Tony Pickering, UK
8:00-8:05	Introduction Marcus Drake, UK
8:05-8:30	Higher CNS centres in lower urinary tract dysfunction Marcus Drake, UK
8:30-8:55	Peripheral pathophysiology in lower urinary tract dysfunction Christopher Fry, UK
8:55-9:20	Spinal cord and brainstem control of the micturition cycle Marcus Drake, UK
9:20-9:30	Micturition suppressing sites in the periaqueductal grey of the rat. Ella Stone, JH Coote, TA Lovick. Birmingham, UK
9:30-9:40	Pre-treatment with purinergic antagonists alter the functional response to methacholine in the inflamed rat urinary bladder. Patrick Aronsson, R Vesela, M Andersson, G Tobin. Gothenburg, Sweden
9:40-9:50	Role of the urothelium in afferent sensitivity to potassium in the mouse bladder Laura-Joy Gooch, DM Daly, CR Chapple, D Grundy. Sheffield, UK
9:50-10:00	Summary and General Discussion
10:00-10:15	COFFEE BREAK
10:15-11:00	PLENARY LECTURE 2 Introduced by Michael J. Joyner, USA The Spectrum of Baroreflex Failure David Robertson, Vanderbilt University, Nashville, TN, USA
11:00-13:00	Poster Session I
13:00-14:00	Lunch & Trade Display (Exhibits) and CAR Editorial Board Meeting
14:00-16:00	Symposia 3 and 4
Symposium 3 Functional Imaging of the Brainstem and Cortical Sites of Autonomic Control in Human Subjects Chair: Vaughan Macefield, Australia
14:00-14:25	Does the cortical autonomic network "listen" or "speak" during cardiovascular arousal? Kevin Shoemaker, Canada
14:25-14:50	Neural correlates of the autonomically mediated integration of emotion and bodily state Marcus Gray, UK
14:50-15:15	Identification of sites of sympathetic outflow during concurrent recordings of sympathetic nerve activity and fMRI Cheree James, Australia
15:15-15:40	Structural and functional brain alterations in sleep disordered breathing Ron Harper, USA
15:40-15:55	Importance of the medial amygdala to the neurogenic hypertension in Schlager mice Kristy Jackson, TP Nguyen-Huu, K Palma-Rigo, PJ Davern, GA Head. Melbourne, Australia
15:55-16:00	General Discussion
16:00-16:15	COFFEE BREAK
Symposium 4 Neural Disorders of the Gastrointestinal Tract: Mechanisms and Prospects for Treatment Chairs: Patricia Castelucci, Brazil and David Linden, USA
14:00-14:05	Introduction and welcome Patricia Castelucci, Brazil
14:05-14:35	A common neuropathological mechanism of action for postoperative-, sepsis- and trauma-induced ileus Tony Bauer, USA
14:35-15:05	The physiology and pathophysiology of hydrogen sulfide in the gastrointestinal tract David Linden, USA
15:05-15:25	Disordered colorectal function after spinal cord injury, animal studies point to novel treatments John B. Furness, Australia
15:25-15:30	Introduction to student presentations David Linden, USA
15:30-15:40	Amplification of cholinergic neurotransmission by adenosine released from Interstitial Cells of Cajal at a tripartite myenteric synapse of the rat ileum Isabel Silva, P Marques, C Vieira, F Ferreirinha, T Magalhães-Cardoso, M Duarte-Araújo, P Correia-de-Sá.
15:40-15:50	The role of NO in intestinal ischemia/reperfusion injury to enteric neurons in mice Leni Rivera, M Thacker, L Pontell, HJ Cho, JB Furness. Melbourne, Australia
15:50-16:00	Effect of obesity on P2X2 receptors and chemical coding in myenteric neurons of male and female (ob/ob) mice Marcia Mizuno, LA Velloso, P Castelucci. Sao Paulo, Brazil
16:00-16:15	COFFEE BREAK
16:15-18:15	Debate: What is Important to Know about Modulation of Sympathetic Transmission Chair: Ian (JC) McGrath, UK
16:15-16:25	Synergy between sympathetic neurotransmitters: molecular, cellular or imaginary? Ian (JC) McGrath, UK
16:25-16:40	Transmission of sympathetic nerve activity into vasoconstrictor tone in humans: the important role of the vascular beta-adrenergic receptors Emma Hart, UK
16:40-16:50	Questions/Debating Points from Floor
16:50-17:05	Neurovascular transmission during natural patterns of nerve activity James A. Brock, Australia
17:05-17:15	Questions/Debating Points from Floor
17:15-17:30	Disruption of vascular neuroeffector transmission in hypertension James J. Galligan, USA
17:30-17:40	Questions/Debating Points from Floor
17:40-17:55	Factors influencing the role of ATP as a vascular sympathetic neurotransmitter William Dunn, UK
17:55-18:15	Questions/Debating Points and General Discussion
18:15-19:15	AAS Business Meeting

WEDNESDAY - SEPTEMBER 14

WEDNESDAY, SEPTEMBER 14, 2011
8:00-10:00	Symposia 5 and 6
Symposium 5 Neuro-Glial-Vascular Mechanisms in the CNS Control of Autonomic Function Chairs: Javier E. Stern, USA and Julian F.R. Paton, UK
8:00-8:30	Modulation of brain neurovascular plasticity by afferent signaling: effects of exercise Lisete Michelini, Brazil
8:30-9:00	Cerebral perfusion: a major determinant of arterial pressure Julian F.R. Paton, UK
9:00-9:30	Neuro-glial-vascular signaling mechanisms influencing neurohumoral integration in the brain Javier E. Stern, USA
9:30-9:45	Autoimplantation of astrocytes into cardiovascular center of brainstem causes sympathoinhibition and decreases the mortality rate in hypertensive rats Takuya Kishi, K Sunagawa. Kyushu, Japan
9:45-10:00	Astrocytes in rat nucleus of the solitary tract are activated by low glucose or glucoprivic challenges DH McDougal, RC Rogers, GE Hermann. Pennington Biomedical Research Center, USA
10:00-10:15	COFFEE BREAK
Symposium 6 Autonomic Dysfunction in Obesity: Consequences and Mechanisms Chair: Kamal Rahmouni, USA
8:00-8:30	Autonomic dysfunction in obesity: Insights from clinical studies Elisabeth Lambert, Australia
8:30-9:00	A role for gastrointestinal brain-derived neurotrophic factor in metabolic and autonomic regulation Edward A. Fox, USA
9:00-9:30	Sympathetic nerve activation in obesity: Mechanistic insights Kamal Rahmouni, USA
9:30-9:45	Hypertension in obesity-prone Sprague-Dawley rats is associated with blunted renal sympathoinhibitory and regional vasodilator responses to gastric peptides Daniela M. Sartor, JMY How, T Pumpa. Melbourne, Australia
9:45-10:00	Regulation of sympathetic nerve activity by AMPA and NMDA receptors in the rostral ventrolateral medulla of obese Zucker rats Domitila A. Huber, AM Schreihofer, Fort Worth, TX, USA
10:00-10:15	COFFEE BREAK
10:15-11:00	PLENARY LECTURE 3 The Autonomic Nervous System in Body Protection and Pain Wilfrid Janig, Physiologisches Institut Introduced by Sergio Cravo, Brazil Christian-Albrechts-Universität Kiel, Germany
11:00-13:00	Poster Session II
13:00-14:00	Lunch & Trade Display (Exhibits)
14:00-16:00	Symposia 7 and 8
Symposium 7 Pathophysiology of Obstructive Sleep Apnea: From Animal Models to Consequences to Human Health Chairs: Mark W. Chapleau, USA and Sérgio L. Cravo, Brazil
14:00-14:30	Molecular mechanisms of chemoreceptor activation and sustained sympathoexcitation in disease Mark W. Chapleau, USA
14:30-15:00	Cardiovascular responses to obstructive sleep apnea: are chemoreceptors as important as we think? Sérgio L. Cravo, Brazil
15:00-15:30	Sleep apnea, arrhythmias and sudden death Virend Somers, USA
15:30-15:45	Neurobehavioral and autonomic dysfunction in obstructive sleep apnea Juan Idiaquez, R Del Rio, R Iturriaga, J Santin, I Santos. Chile
15:45-16:00	Electrophysiological properties of expiratory and pre-sympathetic neurons in the ventrolateral of rats submitted to chronic intermittent hypoxia Davi José de Almeida Moraes, DB Zoccal, BH Machado. Ribeirao Preto, Brazil
16:00-16:15	COFFEE BREAK
Symposium 8 Autonomic Neuro-Immunomodulation: The Interplay between Two Integrative Systems – Nervous and Immune Systems Chair: Valdo José Dias da Silva, Brazil
14:00-14:25	Signaling the brain in systemic inflammation: The role of perivascular cells Jordi Serrats, USA
14:25-14:50	Stress-dependent hypertension and the role of T lymphocytes Paul Marvar, USA
14:50-15:15	Control of intrathymic cellular interactions by hormones and neuropeptides Wilson Savino, Brazil
15:15-15:40	Neuro-immunomodulation in Chagasic cardiomyopathy Marcus Paulo R. Machado, USA
15:40-15:55	Identifying rat sympathetic neurons that regulate immune function Bradford Bratton, D Martelli, MJ McKinley, D Trevaks, RM McAllen. Melbourne, Australia
15:55-16:00	General Discussion
16:00-16:15	COFFEE BREAK
16:15-18:15	Symposia 9 and 10
Symposium 9 Autonomic Control of Body Temperature Chair: Shaun Morrison, USA
16:15-16:40	TRP channels in thermoregulation Andrej Romanovsky, USA
16:40-17:05	Stress-induced hyperthermia Kazuhiro Nakamura, Japan
17:05-17:30	The preoptic hypothalamus and thermoregulation Robin McAllen, Australia
17:30-17:55	Brainstem pathways contributing to thermoregulation Shaun Morrison, USA
17:55-18:10	Leptin amplifies the action of thyrotropin releasing hormone in the nucleus of the solitary tract: implications for thermogenesis Grelinda E. Hermann, RC Rogers. Baton Rouge, LA
18:10-18:15	General Discussion
18:15-18:30	COFFEE BREAK
Symposium 10 Glia-Neuron Interactions in Autonomic Neuroscience Chair: Benedito H. Machado, Brazil
16:15-16:40	Astroglial control of the respiratory and autonomic activities Alexander Gourine, UK
16:40-17:05	On the regulation of synapses in the hypothalamic neuro-hypophyseal system by glia- Grant Gordon, Canada
17:05-17:30	The role of glia in the purinergic modulation of the preBötzinger complex inspiratory rhythm generating network Gregory Funk, Canada
17:30-17:55	Glial–neural interactions in brainstem autonomic control Richard C. Rogers, USA
17:55-18:15	General Discussion
18:15-18:30	COFFEE BREAK
Hot Topic Platform Presentations by Trainees/Junior Scientists – I Chairs: Vaughan Macefield, USA and "to be named"
18:30-18:45	Neurochemically coding functional subpopulations of rat sympathetic preganglionic neurons activated after glucoprivation Lindsay Parker, NN Kumar, AK Goodchild. Sydney, Australia
18:45-19:00	P2X7 receptor-dependent intestinal afferent hypersensitivity in a mouse model of post-infectious irritable bowel syndrome Christopher Keating, P Pelegrin, CM Martinez, D Grundy. Sheffield, UK
19:00-19:15	Transient changes in BDNF parallel plasticity observed in the IML following distal axon injury Aminata Coulibaly, BF Walsh, LG Isaacson. Oxford, OH, USA
19:15-19:30	Aging is associated with reduced white matter connectivity and fractional anisotropy in cortical autonomic regions Ruma Goswami, KN Norton, MF Frances, HA Sharma, JK Shoemaker. Ontario, Canada
19:30	CONGRESS DINNER

THURSDAY - SEPTEMBER 15

THURSDAY, SEPTEMBER 15, 2011
8:00-10:00	Symposia 11 and 12
Symposium 11 The Battle between Brain Disease and Heart Health Chair: William T. Talman, USA
8:00-8:05	Introduction William T. Talman, USA
8:05-8:30	Psychological depression and heart disease Angela Grippo, USA
8:30-8:55	Subarachnoid hemorrhage and the heart Jonathon Zaroff, USA
8:55-9:20	Selective lesions in the Nucleus Tractus Solitarii and sudden death in rats William T. Talman, USA
9:20-9:45	CNS mechanisms and heart failure Frans H.H. Leenen, Canada
9:45-10:00	Analysis and treatment of cardiac alterations in an animal model of anxio-depressive pathologies Caroline Sévoz-Couche, F Camus, ML Bourhis, C Becker, JJ Benoliel. Paris, France
9:55-10:00	General Discussion
10:00-10:15	COFFEE BREAK
Symposium 12 The Osmopressor Response – A Newly Discovered Pathway for Cardiovascular Regulation Chairs: Satish R. Raj, USA and Jens Jordan, Germany
8:00-8:05	Introduction by Chairs
8:05-8:30	Water: A surprising treatment for orthostatic hypotension Jens Jordan, Germany
8:30-8:55	Water: A new treatment for blood phobia syncope Chih Cherng Lu, Taiwan
8:55-9:20	The osmopressor response – What have we learned from the mouse? Julia McHugh, USA ;
9:20-9:45	Molecular and cellular afferent transduction mechanisms of the osmopressor response Gary Lewin, Germany
9:45-10:00	General Discussion
10:00-10:15	COFFEE BREAK
10:15-11:00	PLENARY LECTURE 4 Neural Mechanisms of Chronic Pain: Lessons from Translational Studies of Endometriosis Introduced by Janet Keast, Australia Karen J. Berkley, Florida State University, USA
11:00-13:00	Poster Session III
12:45-14:00	Lunch & Trade Display (Exhibits)and AAS Board Meeting
14:00-16:00	Symposia 13 and 14
Symposium 13 Drug and Exercise Therapy for Postural Orthostatic Tachycardia Syndrome (POTS) Chairs: Michael J. Joyner, USA and David Robertson, USA
14:00-14:25	From syndrome to genes and back – controversies and future directions Emily M. Garland, USA
14:25-14:50	Drug therapy for POTS, past present and future? Satish R. Raj, USA
14:50-15:15	Lessons from exercise physiology and spaceflight for POTS Benjamin Levine, USA
15:15-15:40	The Dallas exercise intervention for POTS Qi Fu, USA
15:40-15:55	Postural orthostatic tachycardia syndrome, chromatin regulation and the noradrenaline transporter gene Richard Bayles, Melbourne, Australia
15:55-16:00	General Discussion
16:00-16:15	COFFEE BREAK
Symposium 14 Autonomic Control and Its Relationship with Biological Cycles Pascal Carrive, Australia and Rodrigo Cunha Alvim de Menezes, Brazil
14:00-14:30	Endogenous circadian control of autonomic, cardiovascular and metabolic function Frank A.J.L. Scheer, USA ;
14:30-15:00	Ultradian rhythmicity in autonomic and behavioural parameters Bill Blessing, Australia and Youchirou Ootsuka, Japan
15:00-15:30	Ultradian rhythms of mammalian energy metabolism and their relationship to food availability and ambient temperature Carola Meyer and Gerhardt Heldmaier, Germany
15:00-15:30	Autonomic control during different sleep stages Matteo Cerri, Italy
16:00-16:15	COFFEE BREAK
Hot Topic Platform Presentations by Trainees/Junior Scientists – II Chairs: Heinrich Lob, USA and to be named
16:15-16:30	Orexin activates brown adipose tissue (BAT) thermogenesis in the rat Tupone Domenico, Madden CJ; Morrison SF. Portland, OR, USA
16:30-16:45	Sympathetic over activity occurs before the hypertension in the two-kidney one clip model Elizabeth Oliveira-Sales, AP Abdala, E Colombari, RR Campos, JFR Paton. Sao Paulo, Brazil and Bristol, UK
16:45-17:00	An increased contribution of L-type Ca2+ channels to activation of vascular muscle underlies spinal cord injury-induced augmentation of neurovascular transmission in rat tail artery Hussain Said Al Dera, MD Habgood, JB Furness, JA Brock. Melbourne, Australia
17:00-17:15	Angiotensin type 1A receptors transfected into the A1 neurons inhibit baroreflex gain and the cardiovascular response to stress in AT1A–/– mice Kesia Palma-Rigo, TP Nguyen-Huu, PJ Davern, JK Bassi, JL Elghozi, AM Allen, Head GA. Melbourne, Australia and Paris, France
17:15-17:30	Sympathetic activation after myocardial infarction in the rat: role of the arterial baroreflex, cardiac afferent reflexes and sex Carolyn Barrett, MI Pinkham. Auckland, New Zealand
17:30-17:45	Balancing resting arterial pressure and sympathetic nerve activity: influence aging in women Emma Hart, N Charkoudian, BG Wallin, TB Curry, MJ Joyner. Rochester, MN, USA
17:45-18:00	The norepinephrine paradox in hereditary sensory and autonomic neuropathy type IV Lucy Norcliffe-Kaufmann, FB Axelrod, H Kaufmann. New York City, USA
18:00-19:00	ISAN Business Meeting

FRIDAY - SEPTEMBER 16

FRIDAY, SEPTEMBER 16, 2011
8:00-10:00	Symposia 15 and 16
Symposium 15 The Cardiac Vagal Axis – Recent Developments Chairs: Jack Cheng, USA and Robin McAllen, Australia
8:00-8:25	Structural and functional plasticity in the cardiac vagal axis Jack Cheng, USA
8:25-8:50	Processing of physiological signals by cardiac ganglion cells Tony Pickering, UK
8:50-9:15	What the vagal nerve stimulation can do for the diseased heart? Kenji Sunagawa, Japan
9:15-9:40	Modulation and rescue of vagal neuroeffector transmission David Paterson, UK
9:40-9:55	Reduced heart rate variability in the diabetic heart is reversed by inhibition of glycogen synthase kinase 3 activity Charles M. Welzig, Y Zhang, H-J Park, K Picard, JB Galper. Charleston, SC and Boston, MA
9:55-10:00	General Discussion
10:00-10:15	COFFEE BREAK
Symposium 16 Oxidative Stress and Autonomic Function Chairs: Valdir A. Braga, Brazil and Eduardo Colombari, Brazil
8:00-8:25	The brain ACE2/Ang-(1-7)Mas receptor axis and oxidative stress Eric Lazartigues, USA
8:25-8:50	Dissecting oxidative stress signaling pathways in forebrain cardiovascular circuits using viral vectors for gene transfer Heinrich Lob, USA
8:50-9:15	Oxidant signaling in the hindbrain modulates salt appetite in hypertension Steve Mifflin, USA
9:15-9:40	Sympathetic vasomotor control by oxidative stress in renovascular hypertension Ruy R. Campos, Brazil
9:40-9:55	SFO-targeted (pro)renin receptor deletion attenuates hypertension is associated with reduced oxidative stress in human renin-angiotensinogen transgenic mice. W Li, H Peng, SJ McDaniels, CD Sigmund, Yumei Feng. New Orleans, Louisiana, and Iowa City, IA, USA
9:55-10:00	General Discussion
10:00-10:15	COFFEE BREAK
10:15-11:00	PLENARY LECTURE 5 Biomarkers, Mechanisms, and Treatment of Autonomic Failure in Parkinson Disease and Related Disorders Introduced by David Robertson, USA David S. Goldstein, Clinical Neurology Section NINDS, NIH, Bethesda, MD, USA
11:00-13:00	Poster Session IV
13:00-14:00	Lunch & Trade Display (Exhibits)
14:00-16:00	Symposia 17 and 18
Symposium 17 ole of the Vagus Nerve in Pain and Inflammation Chair: David Grundy, UK
14:00-14:30	Vagal nutrient signaling and immunoprotection Wim A. Buurman, The Netherlands
14:30-15:00	Vagally-mediated intestinal immune response Wouter de Jonge, The Netherlands
15:00-15:30	Determinants and modulators of vagal nociceptors Marian Kollarik, USA
15:30-15:45	Vagal afferents: nociception and antinociception David Grundy, UK
15:45-16:00	Evidence for neuroepithelial bodies (NEBs) as vagal mechanotransducers in the intrapulmonary mouse airway epithelium Robrecht Lembrechts, I Brouns, K Schnorbusch, I Pintelon, JP Timmermans, D Adriaensen. Antwerp, Belgium
16:00-16:15	COFFEE BREAK
Symposium 18 Cardiac Sympathetic Neuroplasticity: Implications for Health and Disease Chairs: Peter G. Smith, USA and Beth Habecker, USA
14:00-14:25	Sympathetic neurotransmission in the cardiac system: Functional plasticity and regulation by target-derived factors Susan Birren, USA
14:25-14:50	Neurotrophins and cytokines induce remodeling of cardiac sympathetic nerves after ischemia-reperfusion Beth Habecker, USA
14:50-15:15	Cholinergic transdifferentiation of cardiac sympathetic nerves in heart failure Keiichi Fukuda, Japan
15:15-15:40	Changes in cardiac sympathetic innervation in response to pharmacotherapy Peter G. Smith, USA
15:40-15:55	Cardiac sympathetic denervation in symptomatic and asymptomatic carriers of the E46K mutation in the synuclein gene Beatriz Tigero Merino, JC Gomez-Esteban, H Kaufmann, V Llorens, JJ Zarranz. Cruces Hospital, Spain and New York City, USA
15:55-16:00	General Discussion
16:00-16:15	COFFEE BREAK
16:15-17:00	CLOSING PLENARY LECTURE Baroreceptors and the Cardiovascular Autonomic Control: 50 Years from Basic Research to Clinical Application Introduced by Benedito Machado, Brazil Eduardo M. Krieger, Heart Institute (InCor), University of São Paulo, Brazil
17:00	CLOSING CEREMONY AND ANNOUNCEMENT OF ELSEVIER AWARDS